Positive regulation of cytokine production involved in immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytokine production involved in immune response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE4, CPED1, and SSB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLE4 grouped by Positive regulation of cytokine production involved in immune response-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TLE4 →	-1.979	-0.645	.001	.002	3	4
CNS	CPED1 →	-1.915	-0.869	.003	.008	3	4
CNS	SSB →	+0.421	+0.832	<.001	.001	3	4
STOMACH	IFT27 →	-0.970	-0.728	<.001	.008	3	3
STOMACH	SNRPA1 →	+0.656	+1.280	<.001	.003	3	3
STOMACH	TSNARE1 →	-1.345	-0.747	.006	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLE4 by Positive regulation of cytokine production involved in immune response activity — BREAST

Explore this box plot interactively →