Regulation of natural killer cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Regulation of natural killer cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DMA, HLA-F, and HLA-B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell mediated immunity activity versus HLA-DMA in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HLA-DMA →	+0.743	+0.171	<.001	.001	3	6
GBM	HLA-F →	+0.964	+0.275	<.001	<.001	3	6
COAD	HLA-B →	+0.734	+0.207	.008	.004	3	6
HNSC	CXCL9 →	+1.705	+0.216	<.001	.001	3	6
HNSC	GBP4 →	+1.360	+0.216	<.001	.001	3	6
LSCC	SLAMF6 →	+0.847	+0.338	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002715 vs HLA-DMA — GBM

Explore this scatter interactively →