Regulation of natural killer cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of natural killer cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, HLA-B, and HLA-C, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of natural killer cell mediated immunity activity versus B2M in CNS (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	B2M →	+2.146	+0.454	<.001	<.001	3	14
STOMACH	HLA-B →	+3.573	+0.343	.006	.005	2	14
CNS	HLA-C →	+3.375	+0.423	.002	.001	3	12
SOFT_TISSUE	PSMB8 →	+5.682	+0.502	<.001	.003	3	12
CNS	TAP1 →	+2.165	+0.414	.001	<.001	3	11
BREAST	HLA-A →	+2.691	+0.430	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002715 vs B2M — CNS

Explore this scatter interactively →