Negative regulation of B cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCAF1_S614, SPAG1_S418, and TNS2_S120, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell mediated immunity activity versus SCAF1_S614 in LSCC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SCAF1_S614 →	-1.166	-0.096	.001	<.001	3	5
COAD	SPAG1_S418 →	-0.585	-0.039	.006	.001	3	5
LSCC	TNS2_S120 →	+0.503	+0.073	.003	.001	3	5
LUAD	C1orf198_S175 →	+0.769	+0.074	<.001	.001	3	5
LUAD	MTUS1_S1224 →	+0.734	+0.051	.009	.009	3	5
LUAD	CCDC93_S305 →	-0.837	-0.089	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002713 vs SCAF1_S614 — LSCC

Explore this scatter interactively →