Negative regulation of B cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASF1A, UBE2N, and HSP90AA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell mediated immunity activity versus ASF1A in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASF1A →	-0.468	-0.487	.002	.008	3	4
LUAD	UBE2N →	-0.238	-0.142	.008	.008	2	5
OV	HSP90AA1 →	-0.647	-0.175	.001	.001	3	4
UCEC	HSBP1 →	-0.554	-0.389	<.001	<.001	3	4
LUAD	COPS4 →	-0.208	-0.227	<.001	<.001	3	4
LUAD	G3BP2 →	-0.271	-0.232	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002713 vs ASF1A — BRCA

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