Negative regulation of B cell mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BCL6_S343, BCL6_S404, and BCL6_S333, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell mediated immunity activity versus BCL6_S343 in HNSC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BCL6_S343 →	+0.601	+0.319	<.001	<.001	3	5
BRCA	BCL6_S404 →	+0.851	+0.713	<.001	<.001	3	5
GBM	BCL6_S333 →	+0.528	+0.327	<.001	<.001	3	4
UCEC	BCL6_S457 →	+0.896	+0.416	<.001	.002	2	5
OV	RIN3_S524 →	+1.088	+0.229	.003	<.001	3	2
OV	RPS6KC1_S664 →	-1.525	-0.388	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002713 vs BCL6_S343 — HNSC

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