Negative regulation of B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNGAP1, DHX58, and RIPOR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYNGAP1 grouped by Negative regulation of B cell mediated immunity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYNGAP1 →	+1.671	+0.615	<.001	.003	3	5
OVARY	DHX58 →	+0.926	+0.741	.003	.006	3	4
BLOOD_Lymphoma	RIPOR1 →	-2.656	-2.098	<.001	<.001	3	4
LUNG_NSCLC_LUAD	LRFN3 →	+0.970	+0.818	<.001	.005	3	4
BREAST	MYBL2 →	-1.025	-0.832	.004	.006	3	4
BREAST	BUD13 →	-0.681	-0.982	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYNGAP1 by Negative regulation of B cell mediated immunity activity — BLOOD_Leukemia

Explore this box plot interactively →