Regulation of B cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of B cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2orf15, RPN2, and SLC38A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C2orf15 grouped by Regulation of B cell mediated immunity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C2orf15 →	+0.524	+0.706	<.001	.002	3	4
URINARY_TRACT	RPN2 →	+0.997	+0.274	<.001	.009	3	3
OVARY	SLC38A6 →	-0.888	-0.894	.006	.001	3	3
OVARY	VAMP5 →	+1.726	+0.806	.009	.008	2	4
OVARY	GLIS1 →	-0.393	-0.567	.008	.008	2	4
OVARY	B3GNT3 →	+1.715	+0.621	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C2orf15 by Regulation of B cell mediated immunity activity — CNS

Explore this box plot interactively →