Positive regulation of T cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-C, B2M, and HLA-B, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell mediated immunity activity versus HLA-C in STOMACH (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HLA-C →	+3.354	+0.361	<.001	.003	3	14
BREAST	B2M →	+2.328	+0.478	<.001	<.001	3	13
STOMACH	HLA-B →	+4.140	+0.340	.002	.005	2	14
BONE	PSMB9 →	+4.050	+0.402	<.001	.003	3	12
BREAST	HLA-A →	+3.842	+0.440	<.001	<.001	3	12
SOFT_TISSUE	PSMB8 →	+4.990	+0.582	<.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002711 vs HLA-C — STOMACH

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