Regulation of T cell mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of T cell mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, B2M, and HLA-A, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell mediated immunity activity versus HLA-B in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HLA-B →	+3.448	+0.315	<.001	<.001	3	12
BREAST	B2M →	+1.969	+0.291	<.001	<.001	3	11
BREAST	HLA-A →	+3.035	+0.294	<.001	<.001	3	9
STOMACH	PSMB8 →	+2.858	+0.316	.006	.009	3	8
BONE	PSMB9 →	+5.140	+0.498	.006	.001	3	8
BREAST	TAP1 →	+1.659	+0.308	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002709 vs HLA-B — BLOOD_Leukemia

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