Positive regulation of lymphocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B2M, HLA-C, and HLA-B, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte mediated immunity activity versus B2M in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	B2M →	+2.240	+0.394	<.001	<.001	3	15
STOMACH	HLA-C →	+3.277	+0.299	<.001	.002	3	13
BREAST	HLA-B →	+3.675	+0.320	<.001	<.001	3	13
BREAST	PSMB8 →	+2.819	+0.326	<.001	<.001	3	12
BREAST	HLA-A →	+3.623	+0.358	<.001	<.001	3	10
BONE	TAP1 →	+2.787	+0.373	.002	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002708 vs B2M — BREAST

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