Negative regulation of lymphocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, HLA-C, and HLA-E, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte mediated immunity activity versus HLA-B in LIVER (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HLA-B →	+3.961	+0.150	<.001	<.001	3	16
BONE	HLA-C →	+3.518	+0.153	<.001	<.001	3	14
LUNG_SCLC	HLA-E →	+2.894	+0.148	<.001	<.001	3	14
BONE	PSMB9 →	+3.727	+0.122	<.001	<.001	3	14
SOFT_TISSUE	HLA-F →	+2.234	+0.147	.001	.003	3	13
BREAST	HLA-A →	+3.323	+0.131	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002707 vs HLA-B — LIVER

Explore this scatter interactively →