Regulation of lymphocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBPL8, H2AC16, and SH3GL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OSBPL8 grouped by Regulation of lymphocyte mediated immunity-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OSBPL8 →	-0.627	-0.855	.001	<.001	3	3
BONE	H2AC16 →	-0.821	-1.161	.006	.001	3	3
OVARY	SH3GL1 →	-0.741	-0.953	.001	.001	3	3
STOMACH	ARL17A →	-1.143	-1.518	<.001	<.001	2	4
CNS	CDH6 →	-2.530	-0.916	.003	<.001	3	2
CNS	GMPR →	-1.483	-0.826	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSBPL8 by Regulation of lymphocyte mediated immunity activity — CNS

Explore this box plot interactively →