Positive regulation of leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLC1, ZDHHC2, and BACE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DLC1 grouped by Positive regulation of leukocyte mediated immunity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DLC1 →	-1.452	-0.733	.004	.004	3	4
CNS	ZDHHC2 →	-1.176	-0.908	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	BACE1 →	-1.066	-0.168	.003	.002	3	3
LIVER	SIGLEC12 →	+0.035	+0.241	.006	.008	3	3
OESOPHAGUS	TSNARE1 →	-1.836	-0.229	<.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	TMEM43 →	-1.049	-0.196	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DLC1 by Positive regulation of leukocyte mediated immunity activity — SKIN

Explore this box plot interactively →