Negative regulation of leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-G, ZYX, and HLA-B, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte mediated immunity activity versus HLA-G in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HLA-G →	+2.507	+0.243	<.001	<.001	3	14
LUNG_NSCLC_LUSC	ZYX →	+2.115	+0.379	.004	.002	3	11
BREAST	HLA-B →	+2.588	+0.305	.001	.004	2	12
BLOOD_Leukemia	HLA-A →	+2.510	+0.480	<.001	<.001	3	10
STOMACH	B2M →	+2.217	+0.304	.003	.008	2	10
SKIN	NECTIN2 →	+1.188	+0.222	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002704 vs HLA-G — BLOOD_Lymphoma

Explore this scatter interactively →