Regulation of leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, ECE1, and HLA-A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte mediated immunity activity versus HLA-B in PANCREAS (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HLA-B →	+2.847	+0.134	.005	.002	3	9
OVARY	ECE1 →	+1.535	+0.236	<.001	<.001	3	8
BREAST	HLA-A →	+3.372	+0.248	<.001	<.001	3	8
BONE	TAP1 →	+2.664	+0.208	.004	.001	3	8
BREAST	HLA-C →	+2.180	+0.297	<.001	<.001	3	8
BREAST	NLRC5 →	+1.531	+0.234	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002703 vs HLA-B — PANCREAS

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