Positive regulation of immune effector process

Across TCGA cell cohorts, RNA activity of the Positive regulation of immune effector process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, VSIR, and OPTN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of immune effector process activity versus HLA-B in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	HLA-B →	+4.091	+0.273	<.001	.004	3	10
OVARY	VSIR →	+3.002	+0.359	.001	.001	3	10
BLOOD_Lymphoma	OPTN →	+3.254	+0.259	.001	.001	3	10
LARGE_INTESTINE	TIMP2 →	+3.083	+0.259	<.001	<.001	3	9
BONE	MYOF →	+4.621	+0.331	<.001	.001	3	9
BONE	HLA-C →	+3.380	+0.422	.005	.002	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002699 vs HLA-B — STOMACH

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