Positive regulation of immune effector process

Across TCGA cell cohorts, RNA activity of the Positive regulation of immune effector process pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HLA-B, HLA-C, and HLA-A, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of immune effector process activity versus HLA-B in BREAST (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HLA-B →	+3.687	+0.322	<.001	<.001	3	19
KIDNEY	HLA-C →	+3.058	+0.326	<.001	<.001	3	17
BONE	HLA-A →	+3.047	+0.300	<.001	<.001	3	17
STOMACH	TAP1 →	+2.397	+0.284	<.001	<.001	3	16
BLOOD_Lymphoma	TAPBP →	+1.857	+0.238	<.001	<.001	3	15
LARGE_INTESTINE	B2M →	+2.469	+0.275	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002699 vs HLA-B — BREAST

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