Negative regulation of cellular extravasation

Across TCGA patient cohorts, RNA activity of the Negative regulation of cellular extravasation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIF, BRCA2, and NUF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular extravasation activity versus LIF in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LIF →	+0.718	+0.595	.001	.002	3	4
LSCC	BRCA2 →	-0.609	-0.817	<.001	<.001	3	4
LSCC	NUF2 →	-0.578	-0.574	.001	.003	3	4
LSCC	CCSAP →	-0.368	-0.701	.003	.003	3	4
LSCC	PBK →	-0.717	-0.836	<.001	<.001	3	4
LSCC	PARPBP →	-0.559	-0.645	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002692 vs LIF — LSCC

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