Regulation of leukocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte migration pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A5, ARFIP1, and APOM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A5 grouped by Regulation of leukocyte migration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC22A5 →	-0.224	-0.828	<.001	.001	3	6
LARGE_INTESTINE	ARFIP1 →	-0.461	-0.171	<.001	.006	2	7
SOFT_TISSUE	APOM →	-0.266	-1.378	.004	.003	3	5
LARGE_INTESTINE	LONRF2 →	-0.336	-0.228	.003	<.001	3	5
OVARY	IL1A →	-0.521	-0.986	.001	.005	2	5
CNS	SIAH3 →	-0.314	-0.645	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A5 by Regulation of leukocyte migration activity — CNS

Explore this box plot interactively →