Respiratory burst involved in defense response

Across TCGA patient cohorts, RNA activity of the Respiratory burst involved in defense response pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN6, DEF6, and DOCK10, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory burst involved in defense response activity versus PTPN6 in GBM (Pearson r = 0.80).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPN6 →	+0.533	+0.073	<.001	<.001	3	10
GBM	DEF6 →	+0.561	+0.080	<.001	<.001	3	9
LSCC	DOCK10 →	+0.539	+0.127	<.001	<.001	3	9
GBM	HCLS1 →	+0.738	+0.087	<.001	<.001	3	9
COAD	IL4I1 →	+0.799	+0.058	<.001	<.001	3	9
GBM	LCP1 →	+0.615	+0.072	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002679 vs PTPN6 — GBM

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