Respiratory burst involved in defense response

Across TCGA pan-cancer cohorts, RNA activity of the Respiratory burst involved in defense response pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Respiratory burst involved in defense response pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as CESC and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRC, CESC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.547	0.704	<.001	99	view →
CESC	OS	Median	II,III,IV	0.872	0.617	<.001	84	view →
SKCM	OS	Quartile	All	0.529	0.302	.002	36	view →
LUAD	DFS	Quartile	All	0.889	0.718	<.001	30	view →
THYM	OS	Median	All	0.914	1.000	.006	16	view →
COAD	DFS	Tertile	IV	0.375	0.682	.005	14	view →
ESCA	DFS	Median	II,III,IV	1.000	0.452	.023	14	view →
UVM	DFS	Median	All	0.706	0.446	.008	13	view →
LIHC	DFS	Median	All	0.181	0.356	.007	13	view →
ACC	DFS	Tertile	IV	0.782	0.281	.010	9	view →
READ	OS	Quartile	All	0.797	0.959	.012	7	view →
STAD	DFS	Tertile	IV	0.217	0.648	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0002679–KIRC (OS)

Open the KIRC breakdown →