Respiratory burst involved in defense response

Across TCGA patient cohorts, RNA activity of the Respiratory burst involved in defense response pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOK3, SIRPB1, and LILRB2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Respiratory burst involved in defense response activity versus DOK3 in GBM (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DOK3 →	+0.661	+0.176	<.001	<.001	3	10
UCEC	SIRPB1 →	+0.671	+0.255	<.001	<.001	3	9
GBM	LILRB2 →	+0.969	+0.211	<.001	<.001	3	9
OV	NCF1 →	+0.754	+0.236	.001	.001	3	9
COAD	ITGAX →	+0.889	+0.190	.002	.005	3	9
OV	SLC15A3 →	+0.733	+0.181	.005	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002679 vs DOK3 — GBM

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