Regulation of acute inflammatory response

Across TCGA cell cohorts, RNA activity of the Regulation of acute inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF141, GNG14, and STOX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF141 grouped by Regulation of acute inflammatory response-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNF141 →	-0.775	-1.184	.006	.001	3	6
LUNG_NSCLC_LUSC	GNG14 →	+0.410	+1.261	.003	<.001	3	5
CNS	STOX2 →	+0.875	+0.933	.001	.005	3	5
LIVER	CDON →	+1.019	+1.426	.004	<.001	3	4
KIDNEY	EVC →	+1.547	+1.030	.009	.008	3	4
BLOOD_Leukemia	CDK5R1 →	+0.878	+0.989	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF141 by Regulation of acute inflammatory response activity — OVARY

Explore this box plot interactively →