Regulation of tolerance induction

Across TCGA cell cohorts, RNA activity of the Regulation of tolerance induction pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, HLA-C, and B2M, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tolerance induction activity versus HLA-B in OESOPHAGUS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HLA-B →	+3.312	+0.578	<.001	<.001	3	14
OESOPHAGUS	HLA-C →	+2.115	+0.490	<.001	<.001	3	12
BREAST	B2M →	+2.926	+0.399	.005	.002	3	11
BLOOD_Myeloma	TAP1 →	+1.992	+0.575	<.001	<.001	3	10
LIVER	HLA-A →	+3.213	+0.746	<.001	<.001	3	9
BONE	PSMB9 →	+3.553	+0.422	.003	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002643 vs HLA-B — OESOPHAGUS

Explore this scatter interactively →