Negative regulation of immunoglobulin production

Across TCGA patient cohorts, RNA activity of the Negative regulation of immunoglobulin production pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL33, EIF4G1, and FYCO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of immunoglobulin production activity versus IL33 in UCEC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL33 →	+0.762	+0.100	<.001	<.001	3	7
LSCC	EIF4G1 →	-0.223	-0.071	<.001	<.001	3	5
HNSC	FYCO1 →	+0.250	+0.057	<.001	.004	3	5
LSCC	REXO4 →	-0.437	-0.095	<.001	<.001	3	5
LUAD	ADD3 →	+0.409	+0.074	<.001	<.001	3	5
UCEC	DHPS →	-0.421	-0.070	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002638 vs IL33 — UCEC

Explore this scatter interactively →