Negative regulation of immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Negative regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OBI1, ESYT3, and STRN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OBI1 grouped by Negative regulation of immunoglobulin production-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OBI1 →	+0.839	+0.976	.001	.002	3	4
LARGE_INTESTINE	ESYT3 →	+0.947	+0.933	.008	.007	3	4
LARGE_INTESTINE	STRN3 →	+0.771	+0.750	<.001	.002	3	4
LUNG_NSCLC_LUAD	NUS1 →	+0.472	+0.624	.009	.003	3	4
BLOOD_Leukemia	DPAGT1 →	+0.566	+1.025	<.001	.001	3	3
SKIN	EP400 →	+0.370	+0.730	.004	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OBI1 by Negative regulation of immunoglobulin production activity — BLOOD_Leukemia

Explore this box plot interactively →