Negative regulation of immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Negative regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD22, RAC2, and PARP3, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of immunoglobulin production activity versus CD22 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CD22 →	-1.730	-0.172	<.001	<.001	3	14
LUNG_NSCLC_LUSC	RAC2 →	-2.689	-0.153	.002	<.001	3	7
LIVER	PARP3 →	-2.122	-0.233	<.001	.001	3	7
BLOOD_Leukemia	GALE →	-1.040	-0.206	<.001	<.001	3	7
SKIN	TNFRSF14 →	-3.099	-0.186	<.001	<.001	3	7
BLOOD_Leukemia	ADCY7 →	-1.693	-0.183	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002638 vs CD22 — UPPER_AERODIGESTIVE_TRACT

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