Regulation of immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBD2, HUS1, and MPND, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MBD2 grouped by Regulation of immunoglobulin production-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MBD2 →	+0.862	+0.182	.003	.002	3	5
BREAST	HUS1 →	+0.429	+0.168	.007	<.001	3	4
OVARY	MPND →	-0.691	-0.300	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MYO5B →	+1.358	+0.217	.002	.002	3	4
LUNG_SCLC	STX11 →	+0.991	+0.296	.004	.004	3	4
KIDNEY	PELP1 →	-0.728	-0.246	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MBD2 by Regulation of immunoglobulin production activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →