Regulation of germinal center formation

Across TCGA patient cohorts, RNA activity of the Regulation of germinal center formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO1A, DOCK2, and RCSD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of germinal center formation activity versus CORO1A in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CORO1A →	+0.726	+0.085	<.001	<.001	3	10
GBM	DOCK2 →	+0.716	+0.131	<.001	<.001	3	10
HNSC	RCSD1 →	+0.579	+0.117	<.001	<.001	3	10
BRCA	SEPTIN1 →	+0.715	+0.055	<.001	<.001	3	10
HNSC	WAS →	+0.488	+0.110	<.001	<.001	3	10
OV	WIPF1 →	+0.440	+0.049	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002634 vs CORO1A — OV

Explore this scatter interactively →