Regulation of germinal center formation

Across TCGA patient cohorts, RNA activity of the Regulation of germinal center formation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD1D, FCMR, and GAPT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of germinal center formation activity versus CD1D in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD1D →	+0.507	+0.831	.007	.001	2	5
HNSC	FCMR →	+0.720	+0.182	.001	<.001	3	4
HNSC	GAPT →	+0.564	+0.287	<.001	.002	3	4
HNSC	LINC02397 →	+0.481	+0.426	<.001	.001	3	4
PDAC	GPSM2 →	-0.261	-0.166	<.001	.008	3	4
CCRCC	PPP1R16A →	-0.468	-0.556	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002634 vs CD1D — GBM

Explore this scatter interactively →