Regulation of germinal center formation

Across TCGA cell cohorts, RNA activity of the Regulation of germinal center formation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COLEC11, TGFB2, and HCAR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COLEC11 grouped by Regulation of germinal center formation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	COLEC11 →	-0.202	-1.235	.005	<.001	3	4
LUNG_NSCLC_LUSC	TGFB2 →	+0.161	+1.414	.008	<.001	3	4
SOFT_TISSUE	HCAR2 →	-0.136	-1.617	.004	<.001	3	3
LARGE_INTESTINE	POLA1 →	+0.550	+0.865	.001	.003	3	3
BLOOD_Lymphoma	NRN1 →	-0.235	-0.324	<.001	<.001	3	3
PANCREAS	ST7 →	-0.196	-1.152	.002	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COLEC11 by Regulation of germinal center formation activity — STOMACH

Explore this box plot interactively →