Regulation of dendritic cell antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic cell antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NMI, TTYH2, and RNF148, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NMI grouped by Regulation of dendritic cell antigen processing and presentation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NMI →	-1.772	-1.221	.001	<.001	3	4
CNS	TTYH2 →	+1.545	+1.297	.001	<.001	3	4
KIDNEY	RNF148 →	-0.321	-0.938	.002	.005	3	4
BREAST	DUSP4 →	-1.750	-0.746	.005	.004	3	4
LUNG_SCLC	PARP9 →	-1.483	-1.262	.004	.002	3	4
CNS	KSR1 →	+1.033	+0.835	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NMI by Regulation of dendritic cell antigen processing and presentation activity — OVARY

Explore this box plot interactively →