Regulation of dendritic cell antigen processing and presentation

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic cell antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOL4, KCNT1, and FYN, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic cell antigen processing and presentation activity versus NOL4 in BLOOD_Lymphoma (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NOL4 →	+2.639	+0.363	<.001	.009	3	1
BLOOD_Lymphoma	KCNT1 →	+0.058	+0.308	.005	.006	3	1
BLOOD_Lymphoma	FYN →	-2.477	-0.334	.009	.006	3	1
BLOOD_Lymphoma	AIP →	+0.522	+0.263	.002	.001	3	1
BLOOD_Lymphoma	DNAJC6 →	-1.616	-0.244	.005	.004	3	1
BLOOD_Lymphoma	WTIP →	-0.325	-0.248	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002604 vs NOL4 — BLOOD_Lymphoma

Explore this scatter interactively →