Regulation of antigen processing and presentation of peptide antigen

Across TCGA cell cohorts, RNA activity of the Regulation of antigen processing and presentation of peptide antigen pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Linsitinib, Wnt-C59, and Embelin, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Linsitinib grouped by Regulation of antigen processing and presentation of peptide antigen-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Linsitinib →	-0.587	-1.447	.003	.019	3	1
BLOOD_Lymphoma	Wnt-C59 →	-0.705	-1.313	.039	.044	3	1
BLOOD_Lymphoma	Embelin →	-0.401	-1.164	.049	.039	3	1
BLOOD_Lymphoma	Pemetrexed →	-1.025	-1.447	.015	.019	3	1
UPPER_AERODIGESTIVE_TRACT	AGK2 →	+0.644	+0.654	.016	.041	3	1
BLOOD_Lymphoma	PRIMA-1MET →	-1.622	-1.447	.006	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Linsitinib by Regulation of antigen processing and presentation of peptide antigen activity — BLOOD_Lymphoma

Explore this box plot interactively →