Positive regulation of antigen processing and presentation

Across TCGA patient cohorts, RNA activity of the Positive regulation of antigen processing and presentation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1G, ICOS, and CD3E, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of antigen processing and presentation activity versus MYO1G in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1G →	+0.685	+0.124	<.001	<.001	3	6
LSCC	ICOS →	+0.677	+0.455	<.001	<.001	3	6
LSCC	CD3E →	+0.763	+0.538	<.001	<.001	3	6
GBM	HLA-DOA →	+0.723	+0.115	<.001	<.001	3	6
GBM	HLA-DMA →	+0.872	+0.152	<.001	<.001	3	6
COAD	HLA-DRA →	+0.877	+0.076	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002579 vs MYO1G — GBM

Explore this scatter interactively →