Platelet degranulation

Across TCGA cell cohorts, RNA activity of the Platelet degranulation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXA2, FOXD1, and LAD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOXA2 grouped by Platelet degranulation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HOXA2 →	-0.148	-0.486	.001	.003	3	3
KIDNEY	FOXD1 →	+0.219	+0.637	.005	.003	3	3
BLOOD_Leukemia	LAD1 →	+0.101	+1.492	.007	.001	3	3
BLOOD_Leukemia	LRPAP1 →	+0.176	+1.339	.002	.003	3	3
LUNG_SCLC	GNAS →	-0.259	-2.130	.001	<.001	3	2
LUNG_SCLC	MFN1 →	+0.297	+1.275	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOXA2 by Platelet degranulation activity — KIDNEY

Explore this box plot interactively →