Somatic diversification of immune receptors via somatic mutation

Across TCGA patient cohorts, RNA activity of the Somatic diversification of immune receptors via somatic mutation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK2, CDCA8, and MCM5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic diversification of immune receptors via somatic mutation activity versus NEK2 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NEK2 →	+1.212	+0.847	<.001	<.001	3	6
BRCA	CDCA8 →	+1.190	+0.935	<.001	<.001	3	6
HNSC	MCM5 →	+0.684	+0.181	.001	.001	3	5
BRCA	E2F1 →	+1.203	+0.649	<.001	.002	3	5
BRCA	ASF1B →	+1.071	+0.677	<.001	.001	3	5
HNSC	MCM3 →	+0.707	+0.158	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002566 vs NEK2 — BRCA

Explore this scatter interactively →