Somatic diversification of immune receptors via somatic mutation

Across TCGA cell cohorts, RNA activity of the Somatic diversification of immune receptors via somatic mutation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCA2, NCR3LG1, and ZNF211, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMARCA2 grouped by Somatic diversification of immune receptors via somatic mutation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMARCA2 →	-1.051	-0.947	<.001	<.001	3	4
LUNG_SCLC	NCR3LG1 →	+1.561	+1.233	<.001	.006	3	3
KIDNEY	ZNF211 →	+0.989	+0.878	.002	.007	3	3
KIDNEY	NANP →	+0.557	+1.266	.005	.001	3	3
URINARY_TRACT	SKP1 →	-0.859	-1.691	.001	.001	3	3
URINARY_TRACT	CD274 →	+2.739	+1.704	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMARCA2 by Somatic diversification of immune receptors via somatic mutation activity — LUNG_NSCLC_LUAD

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