Mast cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Mast cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP35, MARCHF4, and LINC00211, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mast cell chemotaxis activity versus NUP35 in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NUP35 →	-0.678	-0.722	<.001	<.001	3	4
PDAC	MARCHF4 →	+0.302	+0.414	<.001	<.001	3	4
PDAC	LINC00211 →	+0.171	+0.347	<.001	<.001	3	4
CCRCC	SNORD115-38 →	+0.453	+0.313	.003	.007	3	3
BRCA	GNLY →	+0.901	+0.381	<.001	<.001	3	3
BRCA	DPH3 →	+0.315	+0.329	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002551 vs NUP35 — LSCC

Explore this scatter interactively →