Mast cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Mast cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX9, GULP1, and UBIAD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOX9 grouped by Mast cell chemotaxis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SOX9 →	-2.042	-0.797	.002	.003	3	4
BLOOD_Lymphoma	GULP1 →	+0.565	+2.028	.008	.009	3	4
BLOOD_Leukemia	UBIAD1 →	-0.487	-1.342	.003	.003	3	3
BLOOD_Leukemia	PRELID3A →	+1.974	+1.377	.004	.007	3	3
BLOOD_Leukemia	CD47 →	-1.257	-1.617	.001	.003	3	3
PANCREAS	ETV2 →	-0.698	-0.444	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOX9 by Mast cell chemotaxis activity — BREAST

Explore this box plot interactively →