Chronic inflammatory response

Across TCGA cell cohorts, RNA activity of the Chronic inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R9A, DIRAS1, and ZNF516, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chronic inflammatory response activity versus PPP1R9A in BREAST (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPP1R9A →	-1.105	-1.020	.003	.004	3	4
SKIN	DIRAS1 →	-3.059	-2.214	.005	<.001	3	4
SKIN	ZNF516 →	-1.498	-2.214	<.001	<.001	3	3
OESOPHAGUS	ULBP1 →	-1.736	-2.021	<.001	<.001	3	3
SKIN	PLEK2 →	+4.253	+2.437	.003	<.001	3	3
SKIN	RNF125 →	-4.313	-2.385	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002544 vs PPP1R9A — BREAST

Explore this scatter interactively →