Acute inflammatory response

Across TCGA cell cohorts, RNA activity of the Acute inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP9X, SLC7A5, and GDPD5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP9X grouped by Acute inflammatory response-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	USP9X →	-1.142	-1.377	.003	.001	3	4
BREAST	SLC7A5 →	-1.168	-0.482	<.001	.001	3	4
OESOPHAGUS	GDPD5 →	+1.658	+1.025	.002	.006	3	3
OESOPHAGUS	KRT5 →	-5.308	-0.987	.003	.008	3	3
OESOPHAGUS	ZNF260 →	+1.724	+0.734	.001	.007	3	3
LUNG_NSCLC_LUAD	ZEB1 →	-0.955	-0.518	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP9X by Acute inflammatory response activity — SOFT_TISSUE

Explore this box plot interactively →