Acute inflammatory response

Across TCGA cell cohorts, RNA activity of the Acute inflammatory response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIGAR, SYNCRIP, and IGSF23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acute inflammatory response activity versus TIGAR in BLOOD_Myeloma (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TIGAR →	-1.250	-0.345	.009	.007	3	4
PANCREAS	SYNCRIP →	-0.774	-0.292	<.001	<.001	3	4
BREAST	IGSF23 →	+0.566	+0.228	.004	<.001	3	4
PANCREAS	RGS10 →	-1.725	-0.399	.001	<.001	3	4
PANCREAS	ATP5MC3 →	-0.768	-0.441	<.001	<.001	3	4
PANCREAS	MT-ND3 →	+1.484	+0.404	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002526 vs TIGAR — BLOOD_Myeloma

Explore this scatter interactively →