Immune system development

Across TCGA cell cohorts, RNA activity of the Immune system development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPRT1, MCM7, and CCDC77, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Immune system development activity versus HPRT1 in URINARY_TRACT (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HPRT1 →	+1.284	+0.540	<.001	<.001	3	7
BLOOD_Myeloma	MCM7 →	+1.510	+0.298	.001	<.001	3	6
BREAST	CCDC77 →	+0.865	+0.328	.006	.001	3	5
BLOOD_Myeloma	LSM4 →	+0.784	+0.294	<.001	<.001	3	5
BLOOD_Myeloma	PRIM2 →	+0.859	+0.259	.003	<.001	3	5
URINARY_TRACT	ADAM8 →	-4.086	-0.473	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002520 vs HPRT1 — URINARY_TRACT

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