Peptide antigen assembly with MHC class II protein complex

Across TCGA patient cohorts, RNA activity of the Peptide antigen assembly with MHC class II protein complex pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DQB1, CD74, and HLA-DQA1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide antigen assembly with MHC class II protein complex activity versus HLA-DQB1 in UCEC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HLA-DQB1 →	+1.885	+0.230	<.001	<.001	3	10
UCEC	CD74 →	+1.113	+0.237	<.001	<.001	3	10
OV	HLA-DQA1 →	+1.378	+0.259	<.001	<.001	3	10
GBM	HLA-DRB5 →	+1.963	+0.278	<.001	<.001	3	10
UCEC	HLA-DMA →	+1.230	+0.253	<.001	<.001	3	10
HNSC	HLA-DRA →	+1.463	+0.364	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002503 vs HLA-DQB1 — UCEC

Explore this scatter interactively →