Peptide antigen assembly with MHC class II protein complex

Across TCGA cell cohorts, RNA activity of the Peptide antigen assembly with MHC class II protein complex pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC40A1, BHLHE40, and HLA-DQB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide antigen assembly with MHC class II protein complex activity versus SLC40A1 in SKIN (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC40A1 →	-0.324	-1.556	.009	.003	3	4
BLOOD_Lymphoma	BHLHE40 →	+2.941	+0.588	.002	.003	3	3
BLOOD_Myeloma	HLA-DQB1 →	+4.357	+0.768	.003	.001	3	3
BLOOD_Myeloma	HLA-DRB1 →	+4.636	+0.768	.004	.001	2	4
BLOOD_Myeloma	HLA-DPB1 →	+3.775	+0.768	.003	.001	2	4
BLOOD_Myeloma	HLA-DPA1 →	+4.312	+0.768	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002503 vs SLC40A1 — SKIN

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