Peptide antigen assembly with MHC protein complex

Across TCGA patient cohorts, RNA activity of the Peptide antigen assembly with MHC protein complex pathway is significantly associated with the RNA expression of multiple genes, with the BLCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNASE6, GAPT, and CIITA, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide antigen assembly with MHC protein complex activity versus RNASE6 in BLCA (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNASE6 →	+2.161	+0.169	<.001	<.001	3	34
DLBC	GAPT →	+1.933	+0.105	.001	<.001	3	34
SKCM	CIITA →	+2.271	+0.206	<.001	<.001	3	34
SCLC	CD74 →	+3.419	+0.445	<.001	<.001	3	34
SCLC	HLA-DQA1 →	+3.127	+0.514	<.001	<.001	3	34
SCLC	HLA-DRB5 →	+3.323	+0.341	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002501 vs RNASE6 — BLCA

Explore this scatter interactively →