Peptide antigen assembly with MHC protein complex

Across TCGA cell cohorts, RNA activity of the Peptide antigen assembly with MHC protein complex pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-DRB1, HLA-DRA, and HLA-DPA1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide antigen assembly with MHC protein complex activity versus HLA-DRB1 in LUNG_NSCLC_LUSC (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HLA-DRB1 →	-3.725	-0.307	<.001	<.001	3	16
STOMACH	HLA-DRA →	-2.964	-0.211	.002	.001	3	15
KIDNEY	HLA-DPA1 →	-2.625	-0.199	<.001	<.001	3	15
LUNG_NSCLC_LUSC	HLA-DRB5 →	-1.921	-0.310	.002	<.001	3	13
LIVER	HLA-DPB1 →	-2.469	-0.223	<.001	<.001	3	13
LIVER	HLA-DMA →	-1.887	-0.199	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002501 vs HLA-DRB1 — LUNG_NSCLC_LUSC

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