Peptide antigen assembly with MHC protein complex

Across TCGA cell cohorts, RNA activity of the Peptide antigen assembly with MHC protein complex pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB8, HLA-C, and HLA-F, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide antigen assembly with MHC protein complex activity versus PSMB8 in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PSMB8 →	+4.907	+0.497	.005	<.001	3	16
LUNG_SCLC	HLA-C →	+3.244	+0.208	.001	.008	3	15
BREAST	HLA-F →	+4.029	+0.416	<.001	<.001	3	14
LIVER	PSMB9 →	+5.437	+0.394	.002	.003	2	15
LIVER	TAP1 →	+3.022	+0.371	.001	<.001	3	14
LIVER	HLA-B →	+5.420	+0.470	.002	<.001	1	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002501 vs PSMB8 — LIVER

Explore this scatter interactively →